Salesforce has written a very useful Google Gears application which allows you to use the SalesForce web application offline. What Google Gears does is provide an extension to your browser. This extension includes a tiny database engine, a cache, and a JavaScript library that lets your Web application make use of the database and cache even when not connected to the Web.
You’re on the road meeting a client at a coffee shop, flip open your laptop, and notice that there’s no internet connection. This doesn’t stop you connecting to your Salesforce.com web application and viewing account and contact information though, much to your client’s obvious surprise. While your end users have been able to use Salesforce Offline Edition to access CRM data in this disconnected way, now developers can use new offline technologies to make any of their on-demand applications work off-line.
Related Links
SalesForce Developer Network – Detailed Documentation
Google Gears Blog
I will be attending SalesForce.com’s 
Cisco’s Chairman and CEO, John Chambers will also be keynoting and he will share his vision of collaboration and outlines how organizations need to adapt for the future.
